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Journal of the Korean Wound Management Society 2007;3(2): 73-77. |
| 상품화된 티타늄금속판의 골재생에 미치는 영향의 비교 |
| 한승규ㆍ김우경 |
| 고려대학교 의과대학 성형외과학교실 |
| Effects of Commercially Available Titanium Plates on Osteogenesis |
| Seung-Kyu Han, Woo-Kyung Kim |
| Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea |
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Published online: 30 November 2007. |
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| ABSTRACT |
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This study was designed to compare the effects of commercially available titanium plates on the bone healing in vitro. Human fetal osteoblast cell line was cultivated. Five thousand osteoblasts per well were incubated in a 96-well culture plate with either one of four titanium plates (Osteomed silver plateⰒ, Osteomed gold plateⰒ, Jeil silver plateⰒ, Jeil gold plateⰒ) on top. The medium used in this study was Dulbecco's Modified Eagle's Medium including 5% fetal bovine serum and the titanium plates were cut into squares with 4mm in length. On the 4th day of plating, osteoblast proliferation was determined by MTT method. To measure the production of collagen, the collagen type I carboxy-terminal propeptide enzyme immunoassay was used. Each titanium plate was tested 16 times. There were few differences among control and gold plate groups in osteoblast proliferation and collagen synthesis. However, the silver titanium groups showed less osteoblast survival and collagen synthesis than control and gold titanium groups. Between Osteomed (Addison, TX, U.S.A.) and Jeil Medical (Seoul, Korea) plates, no significant difference was seen in both silver and gold plate groups. These results demonstrated that the coating process of titanium plates could influence the bone healing, and the gold plates were superior to the silver plates on alone culture model. (J Korean Wound Care Soc 2007;3:73-77) |
| Key Words:
Titanium plate, Osteoblast, Bone |
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