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Journal of the Korean Wound Management Society 2016;12(2): 46-50. |
| 3차원 세포 프린팅을 이용한 인공피부 개발 최신 동향 |
| 김병수1ᆞ이희경1ᆞ박주영1ᆞ최영진2ᆞ조동우1 |
| 포항공과대학교 1기계공학과, 2융합생명공학부 |
| 3D Cell-printing of Skin: A State-of-the-art Review |
| Byoung Soo Kim1, Hee-Gyeong Yi1, Ju Young Park1, Yeong-Jin Choi2, Dong-Woo Cho1 |
| 1Department of Mechanical Engineering, 2Division of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Korea |
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Published online: 30 November 2016. |
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| ABSTRACT |
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Beyond the use of skin grafts for wound management, in vitro human skin tissue models have been used for various biomedical and cosmetic applications. In particular, a complete ban on animal testing for cosmetics by the European Union (EU) indicates the need for the development of more biomimetic human skin models that recapitulate complicated microenvironments of native skin. However, current in vitro skin models are still far from ideal in terms of pigmentation, vascularization, and hair follicles due to the reliance on manual fabrication methods. Three-dimensional (3D) cell-printing technology provides a fully automated platform that allows for the highly organized deposition of multiple types of skin cells and biomaterials, which would be hardly realized by the conventional skin tissue engineering approaches. It is obvious that this technique enables us to develop full functional skin models in the future. Here, we provide a current overview of 3D cell-printing of skin. First of all, 3D cell-printing techniques are presented based on working principles: inkjet-based, extrusion-based, and laser-assisted methods. We further present the reported works on skin printing, and share the future directions of the field, followed by conclusions. (J Korean Wound Management Soc 2016;12:46-50) |
| Key Words:
Skin grafts, Human skin tissue models, Three-dimensional (3D) cell printing, Conventional skin tissue engineering approaches |
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