Effect of Hyaluronic Acid Dressing on Diabetic Ulcer Healing- A Pilot Study -

J Korean Wound Management Soc > Volume 10(2); 2014 > Article

Original Article

Journal of the Korean Wound Management Society 2014;10(2): 67-74.

Effect of Hyaluronic Acid Dressing on Diabetic Ulcer Healing- A Pilot Study -

Ye-Na Lee, Tae Kyoung Yun, Seung-Kyu Han

Diabetic Wound Center, Korea University Guro Hospital, Seoul, Korea

Published online: 30 November 2014.

ABSTRACT

To compare the clinical efficacy and safety of hyaluronic acid (HA) dressing with that of conventional dressing materialin the management of diabetic foot ulcers. From May 2013 to February 2014, 19 patients with diabetic foot ulcers wererandomized to either the control group with conventional dressing (n=9) or the experimental group with HA dressing(HealodermTM) (n=10). Weekly assessments containing wound size and depth, wound characteristics, adverse events,and gross photographs were performed by single investigator. Percentages of reduction in terms of wound area andpercentage of increment of healthy granulation tissue were measured for each patient in both groups. By week 3,the mean percentage of wound area reduction was 51.6% in the experimental group and 29.7% in the control group(P=0.184). The mean percentage of wound depth reduction was 59.3% in the experimental group and 50.7% in theexperimental group (P=0.712). In addition, the mean percentage of increment of healthy granulation tissue area was51.7% in the experimental group and 14.6% in the control group (P=0.60). No adverse events related to the studytreatment occurred. HA dressing may have a potential to accelerate the diabetic wound healing. (J Korean WoundManagement Soc 2014;10:67-74)

Key Words: Diabetic foot, Hyaluronic acid dressing