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J Korean Wound Management Soc > Volume 5(2); 2009 > Article
Journal of the Korean Wound Management Society 2009;5(2): 88-93.
특정 펩타이드가 고정화된 PLGA 필름의 연골세포와 섬유아세포의 점착거동
조성배1,2ㆍ박철호1ㆍ박귀덕1ㆍ정동준2ㆍ한동근1
1한국과학기술연구원 바이오소재연구센터, 2성균관대학교 고분자공학과
Adhesion Behavior of Chondrocyte and Fibroblast on Specific Peptide-immobilized PLGA Film
Seong Bae Cho1,2, Chul Ho Park1, Kwideok Park1, Dong Jun Chung2, Dong Keun Han1
1Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, 2Department of polymer Science and Engineering, Sungkyunkwan University, Suwon, Korea
  Published online: 30 November 2009.
ABSTRACT
Poly (lactic-co-glycolic acid) (PLGA) has been widely used in tissue engineering because of its biocompatibility and biodegradation. However, its hydrophobicity typically has some disadventages in the cell adhesion, proliferation, and differentiation. Therefore, this study aims the surface modification of PLGA film using peptide grafting technology. To achieve this purpose, plasma treatment technique was used and then RGD and GVMGFO peptides were chemically grafted through the reactions between carboxylic acid and amine group. For the cell adhesion on these surface-modified PLGA, chondrocytes and fibroblasts were seeded on PLGA-PAA-RGD and PLGA-PAA-GVMGFO films, respectively and then cultured for 24 hours in incubators. The ratio of chondrocyte adhesion increased in the order of the adhesion, PLGA<PLGA-PAA<PLGA-PAA-GVMGFO. Meanwhile, the number of fibroblast adhered to PLGA-PAA-RGD films was greater than that on the PLGA-PAA-GVMGFO films. Therefore, the peptide grafting on PLGA might be suitable to improve the cell adhesion for tissue regeneration. (J Korean Wound Management Soc 2009;5:88-93)
Key Words: PLGA film, Surface modification, RGD, GVMGFO, Cell adhesion
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