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J Korean Wound Management Soc > Volume 5(2); 2009 > Article
Journal of the Korean Wound Management Society 2009;5(2): 79-87.
Salvianolic Acid A Inhibits Scar Formation by Interfering with the Activation of Macrophage and Fibroblast
Geun Woong Kim1,#, Do Hoon Kim2,#, Xiaoyan Sun1, Phan Trong Nhat1, Kyung-Hwan Cho2, Beom-Seok Yang1
1Biomedical Research Center, Korea Institute of Science and Technology, 2Department of Family Medicine, Korea University Medical School, Seoul, Korea
  Published online: 30 November 2009.
ABSTRACT
When Salvianolic acid A isolated from Danshen was applied for the full-excisional wound model in rabbit ear and rat dorsal skin, it showed a biological activity to diminish the scar formation. This activity was correlated with the suppression of macrophage activation. Salvianolic acid A treatment could suppress the stress-related signaling pathways in J774A.1 mouse macrophage cells which was activated by LPS. This suppression was correlated with the inhibition of inducible nitric oxide synthetase expression and focal adhesion kinase activation. In addition Salvianolic acid treatment inhibited the proliferation and migration of rat dermal fibroblast with the reduction of alpha smooth muscle actin expression. Taken together these data suggest that Salvianolic acid A can suppress the scar formation by interfering with the activating signaling pathways of dermal fibroblast and macrophage in wound healing process. (J Korean Wound Management Soc 2009;5:79-87)
Key Words: Salvianolic acid A, Scar, Dermal fibroblast, Macrophage
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