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J Korean Wound Management Soc > Volume 5(1); 2009 > Article
Journal of the Korean Wound Management Society 2009;5(1): 5-10.
햄스터 피부창상 치유에 미치는 rrhGM-CSF의 영향
한규범1ㆍ천용강1ㆍ허시현2ㆍ김완종2
1(주)핸슨바이오텍, 2순천향대학교 생명과학과
Effect of Rice Cell Origin Recombinant Human Granulocyte Macrophage-Colony Stimulating Factor (rrhGM-CSF) on Wound Healing in Hamster Skin
Kyu Boem Han1, Yong Kang Cheon1, Si Hyun Heo2, Wan Jong Kim2
1Hanson Biotech Co., Ltd. Deajeon, 2Department of Life Science, Soonchunhyang University, Asan, Korea
  Published online: 30 May 2009.
ABSTRACT
GM-CSF is a multipotent growth factor, which also plays an important role during the process of wound healing. rrhGM-CSF was specifically produced from rice cell culture in our laboratory. The rrhGM-CSF contains more oligosaccharide side chains than any other types of GM-CSF. This work was taken to evaluate the influence on wound-healing of rrhGM-CSF in male golden hamsters. Full thickness skin defects of 9 mm in diameter were made in the back of hamsters, and 100 Ռl ointment containing rrhGM-CSF 23.9 Ռg/ml was applied. Control groups were given ointment without rrhGM-CSF. The wound sizes were relatively reduced and skin was well regenerated in the experimental group compared with the control group. And also, histologically, reepithelialization and architecture of the skin following injury were prominent in the experimental group. Since this type of GM-CSF has highly glycosylated side chains, the effectiveness might be retain longer and stable, regarding acceleration of wound healing in the animal model. The present study has important implications for further development of the therapeutic manipulation of wound healing using rrhGM-CSF. (J Korean Wound Management Soc 2009;5:5-10)
Key Words: rrhGM-CSF, Wound healing, Hamster
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