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J Korean Wound Management Soc > Volume 4(2); 2008 > Article
Journal of the Korean Wound Management Society 2008;4(2): 74-83.
상흔형성 원인과 조직 재생 기전에 대한 고찰
1KIST 의과학센터, 2육군사관학교 화학과
Biological Mechanism to Control Skin Regeneration and Scar Formation
Beom-Seok Yang1, Nam Taek Lee2
1Biomedical Research Center, Korea Institute of Science and Technology, 2Department of Chemistry, Korea Military Academy, Seoul, Korea
  Published online: 30 November 2008.
Human body responds to its tissue damage by the programmed would healing process. The biological mechanism for the process is basically same for all tissue damages regardless of whether it occurs in skin or inner organs. In this process, immune cells and fibrotic cells play crucial roles with cooperative responses between them. Unfortunately this wound healing process always does not regenerate the damaged tissue as its original state. Instead the tissue repair results in the production of a fibrotic mass so called scar in many cases. We will summarize recent developments in understandings of cellular responses and biological factors to control the wound healing mechanism with focusing on skin tissue repair. We will emphasize especially why and how scar formation happens in skin wound healing. In addition we will discuss current and future therapeutic strategies for the prevention of scar formation. (J Korean Wound Management Soc 2008;4:74-83)
Key Words: Wound healing, Regeneration, Scar, Skin
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