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J Korean Wound Management Soc > Volume 4(1); 2008 > Article
Journal of the Korean Wound Management Society 2008;4(1): 12-15.
쥐에서 성장호르몬이 상처치유에 미치는 영향
허은주ㆍ이상우ㆍ유지한ㆍ장학ㆍ민경원
서울대학교 의과대학 성형외과학교실, 성형재건연구소
The Effect of Growth Hormone on Wound Healing in Rats
Eun Ju Heo, Sang Woo Lee, Ji Han Yoo, Hak Chang, Kyung Won Minn
Department of Plastic & Reconstructive Surgery, Research Institute of Plastic & Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Korea
  Published online: 31 May 2008.
ABSTRACT
The benificial effect on wound healing of the systemic growth hormone (GH), mediated by insulin-like growth factor 1 (IGF-1), is well known. Recent studies have shown that GH facilitates wound healing not by circulating IGF-1 but by local IGF-1 produced in the wound itself. The purpose of this animal experimental study was to examine the influence of topical growth hormone administration on the healing time of wounds in rats. Full thickness skin defects were made in the back of rats, and ointment containing 5 IU/L GH was applied every other day. Control group were given ointment only. The wound sizes were measured every 2 days, and biopsies were taken after 12 days. The wound sizes were significantly reduced in the GH-treated groups as compared with the control group (p<0.05). Histological and immunohistochemical examination revealed that production of IGF-1 in the experimental group increased more than in the control group. The present results suggest that local treatment with GH is effective regarding acceleration of wound healing. (J Korean Wound Management Soc 2008;4:12-15)
Key Words: Growth hormone (GH), Wound healing, IGF-1
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