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Journal of the Korean Wound Management Society 2006;2(2): 68-76. |
| 전기 방사법을 이용한 PLGA와 콜라겐 나노 섬유 부직포의 제조 및 창상피복제로의 응용 |
| 맹만1,2·정경혜1·박석우1·김정철3·권오형4·강인규1 |
| 1경북대학교 고분자공학과, 2중국연변대학 고분자화공학부, 3경북대학교 의과대학 면역학교실, 4금오공과대학 고분자공학과 |
| Electrospinning of PLGA/Collagen Nanofibrous Mats and Their Application to Wound Dressing |
| Wan Meng1,2, Kyung-Hye Jung1, Suk-Woo Park1, Jung-Chul Kim3, Oh Hyung Kwon4, Inn-Kyu Kang1 |
| 1Department of Polymer Science, Kyungpook National University, Daegu, 2Department of Chemical Engineering and Polymer Science, Yanbian University, Yanji, People's Republic of China, 3Department of Immunology, School of Med |
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Published online: 30 November 2006. |
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| ABSTRACT |
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Nanofiber mats have been suggested as a candidate for controlling infection and improving healing effect. Electrospinning is a useful process that produces continuous nanofibers through the action of an external electric field imposed on polymer solution. Poly (lactide-co-glycolide) (PLGA), one of the well-known biodegradable synthetic polymers, and collagen, natural biopolymer, were dissolved in hexafluoropropanol and subsequently electrospun to fabricate nanofiber mats. The diameter of PLGA/Col nanofibers was in the range of 100 to 700 nm. Morphology and surface characteristics of electrospun nanofiber mats examined using SEM, ESCA, and AFM showed that PLGA and collagen were successfully blended and deposited on the surface. To measure the degradation, PLGA/Col nanofiber mats were soaked in enzymatic solution containing collgenase. To observe the cell behavior on the nanofibers, NIH 3T3 fibroblasts were cultured on nanofiber scaffolds and morphology of cells was characterized by SEM. Cell compatibility were investigated using MTT and BrdU assay for the application to wound dressing. The results indicated that viability and proliferation of NIH 3T3 cells on PLGA/Col nanofiber mats were significantly higher than those on PLGA mats. We drew a conclusion that PLGA/Col composite mats were a better candidate than PLGA mats to support wound healing. (J Korean Wound Care Soc 2006;2:68-76) |
| Key Words:
PLGA, Collagen, Electrospinning, Nanofibers |
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