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Journal of the Korean Wound Management Society 2006;2(2): 57-63. |
| 섬유아세포와 히알루론산을 이용한 연부조직의 재생 |
| 박덕준·한승규·이병일·김우경 |
| 고려대학교 의과대학 성형외과학교실 |
| New Protein Repair System Using Fibroblast-Hyaluronic Acid Mixture |
| Doug-John Park, Seung-Kyu Han, Byung-Il Lee, Woo-Kyung Kim |
| Department of Plastic Surgery, Korea University College of Medicine, Seoul, Korea |
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Published online: 30 November 2006. |
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| ABSTRACT |
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This study was undertaken to evaluate the feasibility of Restylane, which is a modified hyaluronic acid, combined with cultured human dermal fibroblasts, to enhance the longevity of injected implants. The effect of adding fibroblast was determined by evaluating weight change of the cell-Restylane mixture, which was injected in nude mice. Macroscopic and microscopic changes were also investigated. The mean weight of the control group nodules decreased throughout the examination period. On the other hand, the mean weight of the test group nodules decreased only over the first 2 weeks. Beyond 2 weeks, there was no further significant weight change. Histological examinations of the control group exhibited negative immunohistochemical staining for human collagen at each examination period. The test group exhibited positive staining after 2 weeks, indicating the presence of human collagen. These results indicate that Restylane mixed with cultured human dermal fibroblasts maybe successfully injected as living grafts for long-term retention of implants. (J Korean Wound Care Soc 2006;2:57-63) |
| Key Words:
Hyaluronic acid, Fibroblast |
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